hVIVO successfully completes RSV challenge study in Older Adults

London, UK – 6 August 2019: hVIVO plc (AIM: HVO), an industry leading clinical development services business pioneering human disease models based upon viral challenge, announces the successful completion of an RSV human challenge study conducted in older adults, aged 60-75 years. The study was conducted at hVIVO’s specialist clinical facility in London.

The study demonstrated that an RSV challenge model can be conducted safely in a population of 60-75 years of age.

The study, which extends hVIVO’s commercial provision beyond the established RSV human challenge model in 18-60 year olds, comprised volunteers who were residential in hVIVO’s state of the art human challenge clinical unit for a period of approximately 2 weeks after being inoculated with hVIVO’s GMP-manufactured RSV Memphis 37 Challenge virus strain. Each volunteer was closely monitored 24 hours a day with data concerning safety, infection rates, virology and symptoms collected before being safely discharged and followed up for 28 days post discharge.

The hVIVO RSV Older Adult challenge model in 60-75 year olds, was specifically designed to provide the pharmaceutical industry with an early clinical development proof of concept platform to safely evaluate novel treatments/vaccines in one of the populations with the greatest unmet medical need.

Dr Trevor Phillips, Executive Chairman, commented:
“We are pleased to announce results from this study in an older adult population and broadening hVIVO’s commercial offering in RSV beyond its already established model in the younger population that is currently the only such RSV model commercially available. These positive results mean we are now able to offer existing and new customers a model that targets a population that is particularly vulnerable to RSV and for use in vaccine or antiviral product development.

The Company’s contract pipeline is experiencing a strong demand for RSV challenge study services and we anticipate this demand will continue reflective of the unmet medical need that companies are addressing.”

For further information please contact:

hVIVO plc Trevor Phillips (Executive Chairman) +44 207 756 1300

Fleur Wood (EVP, Investor Relations & Communications)

Numis Securities Limited +44 207 260 1000 Freddie Barnfield / Huw Jeremy (Nominated Adviser) James Black (Corporate Broking)

FTI Consulting Simon Conway / Victoria Foster Mitchell +44 203 727 1000

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